engleski

Differential innate immune resistance of ovarian corpora lutea and follicles to cytomegalovirus infection

Human cytomegalovirus (HCMV) is a major viral cause of morbidity following congenital infection and a cause of miscarriage during early pregnancy. Employing the murine cytomegalovirus (MCMV) model, we show early pregnancy loss to be due to an exquisite, overwhelming infection of ovarian corpora lutea (CL). Excessive infection of CL granulosa cells, the main producers of progesterone during early pregnancy, was accompanied by a detrimental regulation of key genes involved in the synthesis and degradation of serum progesterone levels and substantial pregnancy loss. In contrast to CL, ovarian follicles are completely resistant to MCMV infection even in highly immunocompromised hosts. Here we have characterized and discussed the mechanisms of differential innate resistance of CL and ovarian follicles to MCMV infection.

MCMV; Ovary

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