engleski

Evaluation of routine prenatal ultrasound detection of fetal gastrointestinal malformations: European multicentric study

We have evaluated the effectiveness of routine prenatal ultrasound screening in detection of selected groups of major gastrointestinal malformations occurring among 690 123 pregnancies monitored from July 1st to December 31st 1998 in 19 European Congenital Malformation Registries. There were 243 cases of abdominal wall defects, 177 cases of diaphragmatic hernia and 386 cases of gastrointestinal atresia/stenosis. Only 57% of cases with diaphragmatic hernia and two thirds of cases of omphalocele compared to 95% of the fetuses with gastroschisis are currently identified in an unselected population offered routine mid trimester ultrasound screening in Europe. Among various cases of atresia/stenosis, the highest detection rate was recorded for duodenal (59%) and anorectal (32%) anomalies. Sensitivity of prenatal ultrasound clearly depends on the type of malformation and the presence of other structural anomalies or chromosomal aberrations. There is also significant variation in detection rates between different European regions reflecting policies, equipment and operators experience. The highest rates of elective termination of pregnancy after prenatal ultrasound diangosis were observed for omphalocele (50 or 36%) and gastroschisis (32 or 30%), and lowest for esophageal atresia (8%).

congenital malformations; prenatal diagnosis; prenatal ultrasound

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