Paraspecificity of Vipera a. ammodytes-specific antivenom towards Montivipera raddei and Macrovipera lebetina obtusa venoms (CROSBI ID 619846)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Kurtović, Tihana ; Lang Balija, Maja ; Ayvazyan, Naira ; Halassy, Beata
engleski
Paraspecificity of Vipera a. ammodytes-specific antivenom towards Montivipera raddei and Macrovipera lebetina obtusa venoms
Antivenom raised against the venom of nose-horned viper, Vipera ammodytes (V. a.) ammodytes (European viper venom antiserum, Zagreb antivenom), contains neutralising equine F(ab')2 fragments that are clinically successful against homologues venom, but also against the venoms of several others medically important European snakes due to its paraspecific action. In this work we demonstrated that Zagreb antivenom is preclinically effective in neutralising lethal toxicity and hemorrhagicity of venoms of Armenian mountain snakes – Montivipera raddei and Macrovipera lebetina obtusa as well. In order to better understand the biochemical basis of the observed paraspecificity, the ability of anti-V. a. ammodytes serum to recognise and neutralise proteinases of the two venoms was also investigated. Anti-V. a. ammodytes serum showed surprisingly low capacity to inhibit metalloproteinases of both venoms included in the study, probably due to weak immunorecognition of their P-I representatives. Also, it completely failed to abolish enzymatic action of serine proteinases from Macrovipera lebetina obtusa venom. Relevance of such finding is yet to be established.
European viper venom antiserum; Zagreb antivenom; Montivipera raddei; Macrovipera lebetina obtusa; Paraspecificity; Snake venom; Snake venom metalloproteinases; Snake venom serine proteinases
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Podaci o prilogu
37-37.
2014.
objavljeno
Podaci o matičnoj publikaciji
Croatian Immunological Society 2014 Annual Meeting, Book of Abstracts
Podaci o skupu
Annual meeting of the Croatian Immunological Society 2014
predavanje
17.10.2014-18.10.2014
Krk, Hrvatska