engleski

Complex interactions of gaseous and particulate emissions, NKT cells and BTEX on people with environmental diseases

Introduction: urban air pollution represents a common and difficult problem in the majority of metropolises, which contain high levels of traffic congestion generating great amounts of genotoxic substances. Volatile organic compounds (VOCs) play an important role in ecological damages, disturbing the ecosystem and human health. It is well-known that the blood-air relationships of benzene, toluene, ethylbenzene, and the xylenes (BTEX) were dependent by smoking, exposure-smoking interactions, and by gender and age, while the other VOCs were not. The objectivities and methods of our study: were to determine the connection between the concentration of BTEX in urine, the immunological status (phenotypic profile of peripheral blood lymphocytes and releasing of cytolitic molecule perforin from these cells) and respiratory illnesses in people from industrial area and those from rural fields. Results: people living in urban industrial fields have significantly diminished values of PIF (inspiratory peak flow), FIVC (inspiratory forced vital capacity), FIV1 (volume inspired in the first second of the test) and FVC (forced vital capacity) and significantly increased the concentration of o-ksilen, benzene, toluene and etilbenzene, as well as the number of NK and NKT cells Conclusion: BTEX-analyze in urine, as an important and easy method represents a good marker in environmental monitoring which contributes better protection of air pollutants and quicker diagnosis of COPD and asthma.

BTEX; NKT; environmental diseases

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