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A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments (CROSBI ID 79263)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ziegler, Heike ; Thale, Regine ; Lučin, Pero ; Muranyi, Walter ; Flohr, Thomas ; Hengel, Hartmut ; Farrell, Helen ; Rawlinson, William ; Koszinowski, Ulrich H. A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments // Immunity, 6 (1997), 1; 57-66-x

Podaci o odgovornosti

Ziegler, Heike ; Thale, Regine ; Lučin, Pero ; Muranyi, Walter ; Flohr, Thomas ; Hengel, Hartmut ; Farrell, Helen ; Rawlinson, William ; Koszinowski, Ulrich H.

engleski

A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments

The principle by which mouse cytomegalovirus blocks antigen presentation in the MHC class I pathway was investigated. The responsible gene m152, encoding a type I transmembrane glycoprotein of 40 kDa, is a member of a gene family located in the right-hand terminal region of the 230 kb virus genome. Expression of m152 in murine and human cells arrested the export of mouse class I complexes from the ER-Golgi intermediate compartment/cis-Golgi compartment and inhibited lysis by cytotoxic T cells. The plasma membrane transport of human MHC class I molecules was not affected. The deletion of the cytoplasmic tail of gp40 did not lift its effect on class I molecule export, indicating that this protein differs in its functions from known immunosubversive viral gene products and represents a novel principle by which a herpesvirus shuts off MHC class I function.

murine cytomegalovirus; viral genes; cytomegalovirus glycoproteins; antigen presentation; MHC class I; immune evasion

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

6 (1)

1997.

57-66-x

objavljeno

1074-7613

Povezanost rada

Temeljne medicinske znanosti, Veterinarska medicina

Indeksiranost