Reactions Catalyzed by Halohydrin Dehalogenases (CROSBI ID 53645)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Majerić Elenkov, Maja ; Szymanski, Wiktor ; Janssen Dick B.
engleski
Reactions Catalyzed by Halohydrin Dehalogenases
In some bacteria, halohydrin dehalogenases catalyze the conversion of vicinal halo alco- hols, such as 1, 3-dichloropropane or 3-chloropropane-1, 2-diol, into epoxides, and thereby play a role in the biodegradation of halogenated organic compounds. In the reverse reaction, i.e. epoxide ring opening, various small anions can replace the halide, allowing the synthesis of β-substituted alcohols, including β-hydroxynitriles and β-azido alcohols. These remarkable catalytic properties have been modified by structure-based protein engineering, making the enzymes suitable for diverse applications.
Epoxides, Hydroxynitriles, Microorganisms, Alcohols, Cyanides
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Podaci o prilogu
507-527.
objavljeno
Podaci o knjizi
Science of Synthesis ; Biocatalysis in Organic Synthesis 2
Faber, Kurt ; Fessner, Wolf-Dieter ; Turner, Nicholas
Stuttgart: Georg Thieme Verlag
2014.
978-3-13-174161-5