engleski

Probiotic strain Lactobacillus plantarum 1K reduces Salmonella enterica serovar Typhimurium infection in mice

The influence of the oral treatment with probiotic strain Lactobacillus plantarum 1K on an oral infection of mice by Salmonella enterica serovar Typhimurium was investigated. Mice were fed with milk-based diets supplemented with L. plantarum 1K for three days prior and following an oral challenge with S. Typhimurium. Survival, competition, adhesion and colonization of L. plantarum 1K and influence on infection with S. Typhimurium were monitored in the gastrointestinal tract. After the oral treatment of mice with L. plantarum 1K in combination with S. Typhimurium, the total number of lactic acid bacteria in faeces and in intestinal homogenates was increased, contrary, the total number of enterobacteria and Salmonella sp. was reduced. These results demonstrate that L. plantarum 1K can reduce the severity of infection due to the pathogenic S. Typhimurium, and suggest that this reduction is associated with competitive exclusion in the intestinal tract conferred by the L. plantarum 1K

probiotic; Lactobacillus plantarum; Salmonella enterica serovar Typhimurium; infection; mice

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