Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria (CROSBI ID 217793)
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Podaci o odgovornosti
Ljubić, Spomenka ; Jazbec, Anamarija ; Tomić, Martina ; Piljac, Ante ; Jurišić Eržen, Dubravka ; Novak, Branko ; Kaštelan, Snježana ; Vučić Lovrenčić, Marijana ; Brkljačić, Neva
engleski
Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria
Aims were to investigate the behaviour of adiponectin (ApN) in patients with type 1 and type 2 diabetic nephropathy. ApN and inflammatory and other markers of the metabolic syndrome were compared across diabetes types, albumin excretion rate (AER), and creatinine clearance (CrCl) categories in 219 type 1 and type 2 diabetic patients. Significant differences among ApN levels according to AER were found in both types of diabetes (𝐹 = 8.45, df = 2, 𝑃 < 0.001).With the progression of albuminuria, ApN increased in type 1 and decreased in type 2 diabetes. Patients with decreased CrCl had higher ApN levels than those with normal CrCl in either type of diabetes (𝐹 = 12.7, df = 1, 𝑃 < 0.001). The best model for ApN (𝑅 2 = 0.9002) obtained from stepwise regression in type 1 diabetes included CrCl, BMI, WBC, CRP, and age, while in type 2 diabetes (𝑅 2 = 0.2882) it included ppPG, LDL, and UA. ApNbehaved differently in relation to albuminuria, increasing with its progression in type 1 diabetes and decreasing in type 2 diabetes. It was however increased in the subgroupswith decreased CrCl in both types of diabetes. Albuminuria seems to be more important than renal insufficiency in the definition of ApN levels in type 1 and type 2 diabetes.
adiponectin; albuminuria; diabetes mellitus
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Podaci o izdanju
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2015.
372796-1-372796-
objavljeno
1687-8337
10.1155/2015/372796
Povezanost rada
Kliničke medicinske znanosti