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izvor podataka: crosbi

Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds (CROSBI ID 218108)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Rogina, Anamarija ; Rico, Patricia ; Gallego Ferrer, Gloria ; Ivanković, Marica ; Ivanković, Hrvoje Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds // European polymer journal, 68 (2015), 278-287. doi: 10.1016/j.eurpolymj.2015.05.004

Podaci o odgovornosti

Rogina, Anamarija ; Rico, Patricia ; Gallego Ferrer, Gloria ; Ivanković, Marica ; Ivanković, Hrvoje

engleski

Effect of in situ formed hydroxyapatite on microstructure of freeze-gelled chitosan-based biocomposite scaffolds

New in situ highly-porous chitosan/hydroxyapatite (CS/HA) biocomposite scaffolds have been prepared via freeze-gelation technique. Different content of in situ synthesized hydroxyapatite within chitosan solution was obtained by changing the amount of calcium and phosphate precursors. The composition of precipitated inorganic phase was characterized by X-ray diffraction analysis (XRD) and Fourier transformed infrared spectroscopy (FTIR), while morphology of scaffolds was imaged by scanning electron microscopy (SEM). SEM observations of cross section and surface area of prepared scaffolds have shown different microstructure and topography regarding to the HA content, which plays an important role in cell adhesion and proliferation, and nutrient transport. The MTT assay of scaffolds with different content of hydroxyapatite has shown no toxicity which is one of the main requirements for potential biomedical application. Likewise, the presented synthesis allows preparing the scaffolds with large and very well interconnected pores without obtaining toxic intermediate products.

chitosan (CS); in situ hydoxyapatite (HA); freeze-gelation; highly-porous structure; cytotoxicity

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Podaci o izdanju

68

2015.

278-287

objavljeno

0014-3057

10.1016/j.eurpolymj.2015.05.004

Povezanost rada

Kemija, Kemijsko inženjerstvo, Biologija

Poveznice
Indeksiranost