Machine learning based analysis of biochemical and morphological parameters in patients with dialysis related amyloidosis (CROSBI ID 482831)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Štambuk, Nikola ; Barišić, Igor ; Wilhem, Vladimir ; Janković, Stipan ; Konjevoda, Paško ; Pokrić, Biserka
engleski
Machine learning based analysis of biochemical and morphological parameters in patients with dialysis related amyloidosis
Dialysis related amyloidosis is defined as an accumulation and deposition of beta2-microglobulin derived fibrils, especially in bones and joints, due to insufficient elimination during therapy. The syndrome has also been reported in patients with slowly progressive renal failure who had never been dialysed. The aim of this study was to analyse biochemical, morphologic and anamnestic parameters that may be relevant for the onset and developement of dialysis related amyloidosis. In addition to standard statistical procedures we also applied the machine learning based methods of data mining to quantify the risk factors for asymptomatic patients. The extraction of risk factors for the onset of the dialysis related amyloidosis syndrome could enable us to predict the symptoms and consider medical procedures to prevent the onset of the disease. The C4.5 machine learning algorithm extracted simple and highly accurate tree for the discrimination of asymptomatic and symptomatic patients suffering from dialysis related amyloidosis. It remains an open question if our findings may contribute to the problem of accurately predicting the onset of dialysis related arthropathy in asymptomatic patients group.
amyloidosis; dialysis; machine learning; risk factors
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Podaci o prilogu
76-x.
2002.
objavljeno
Podaci o matičnoj publikaciji
Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko
Zagreb: Institut Ruđer Bošković
Podaci o skupu
MATH/CHEM/COMP 2002 - The 17th Dubrovnik International Course & Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences
poster
24.06.2002-29.06.2002
Dubrovnik, Hrvatska