engleski

Pregnancy induced changes in innate immuniy during autoimmune thireoid disease

NKT cells represent a unique sublineage of innate lymphocytes, that share the properties of natural killer cells and conventional T cells. Autoimmune thyroid dysfunction (ATD), which comprises two main clinical entities: Graves' disease and Hashimoto thyroiditis, often affect women of reproductive age. In a healthy pregnancy predominant is Th2 over Th1 immunity, which explains the improvement of autoimmune disease during pregnancy, while after birth due to changes in Th1/Th2 ratios often leads to deterioration of ATD. NKT and Tregs seem to play an important part in mediating maternal tolerance to fetus. Although many researches have been done in the field of thyroid autoimmunity, very few studies investigated the role of innate immunity in AITD during human pregnancy and in the postpartal period. We investigated the presence of ATD in pregnant and postpartum period in women with hormonal status determination, the titer of thyroid antibodies and auto antibodies and compared them with healthy pregnant women and subjects’ postpartum and not pregnant women. After intracellular and surface staining using flow cytometry, we analyzed the phenotype and cytolytic potential of isolated peripheral blood mononuclear cells of pregnant women and postpartum women, and not pregnant women. Pregnancy and the postpartum period influence the function of the thyroid gland. In the presence of thyroid autoimmunity changes are more pronounced, especially postpartum. Apart from pregnancy and postpartum period influence the course of ATD and thyroid autoimmunity affects thyroid function in pregnancy and the postpartum period.

autoimmune thireoid disease ; innate immuniy ; pregnancy

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