Crystal structure of the cobalt human insulin derivative (CROSBI ID 219729)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Prugovečki, Biserka ; Ivetić, Natalija ; Matković- Čalogović, Dubravka
engleski
Crystal structure of the cobalt human insulin derivative
The structure of the human cobalt insulin derivative at 1.73 Å resolution is described. Single crystals were prepared by the hanging drop vapour diffusion crystallization method using Zn-free insulin and cobalt(II) acetate. The crystal structure was determined by the single crystal X-ray diffraction method. The investigated insulin derivative exhibits the T6 form of insulin and crystallizes in the trigonal system in space group R3, with the unit cell parameters a = b = 81.43 Å and c = 33.75 Å. There are two cobalt atoms per insulin hexamer which are octahedrally coordinated by three symmetry-related Nε2 atoms of three HisB10/HisD10 and three oxygen atoms from three water molecules.
insulin derivative ; cobalt ; X-ray structure
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Podaci o izdanju
34 (1)
2015.
67-72
objavljeno
1857-5552
1857-5625
10.20450/mjcce.2015.653