Soluble Type III TGFβ Receptor in diagnosis and follow-up of patients with breast cancer (CROSBI ID 219746)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Jurišić, Darko ; Erjavec, Igor ; Trkulja, Vladimir ; Dumić-Čule, Ivo ; Hadžibegović, Irzal ; Kovačević, Lucija ; Svaguša, Tomo ; Stanec, Zdenko ; Vukičević, Slobodan ; Grgurević, Lovorka
engleski
Soluble Type III TGFβ Receptor in diagnosis and follow-up of patients with breast cancer
Type III TGFβ receptor (TGFβrIII) modulates TGFβ superfamily signaling. Its tumor tissue expression is downregulated in human breast cancer. We determined (indirect ELISA) plasma levels of the soluble receptor (sTGFβrIII) in 47 women with breast cancer (AJCC stage 0 to IIB) (cases) pre- surgery and over two months after the surgery, and in 36 healthy women (controls). Plasma sTBFβrIII was lower in cases than in controls (age-adjusted difference -29.7 ng/mL, P<0.001), and discriminated between disease and health (sensitivity and specificity 100% at 16.6 ng/mL). With adjustment for age, AJCC stage, lymph node involvement, HER2 and hormone receptor status, higher pre-surgery sTBFβrIII was associated with better progression-free survival (HR=0.68, 95%CI 0.49- 0.89, P=0.004). An increasing trend in plasma sTBFβrIII was observed over 2 months after the surgery (0.6% increase/day, P<0.001), consistently across the patient subsets. Data suggest a high potential of plasma sTBFβrIII as a novel diagnostic and prognostic biomarker in breast cancer.
TGFβ; TGFβrIII; betaglycan; breast cancer; biomarker
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti