LC-NMR analysis of impurities in a key starting material of Etodolac (CROSBI ID 626077)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Biljan, Ivana ; Car, Željka ; Jednačak, Tomislav ; Pičuljan, Katarina ; Ribić, Rosana ; Habinovec, Iva ; Galić, Nives ; Tomić, Srđanka ; Novak, Predrag
engleski
LC-NMR analysis of impurities in a key starting material of Etodolac
Tryptophols are derivatives of 2-(1H-indol-3-yl)ethanol, indole class bearing a C-3 hydroxyethyl side chain. 7-Ethyltryptophol, 2-(7-ethyl-1H-indol-3-yl)ethanol, is a key starting material in the synthesis of Etodolac, an important non-steroidal anti-inflammatory drug. The currently available synthetic procedures for 7-ethyltryptophol usually result with formation of a high-level of various impurities. LC-NMR is a very powerful tool for obtaining detailed structural information of components in complex mixtures such as impurities and metabolites in pharmaceuticals, natural products and synthetic polymers. In the present study, we developed LC-NMR methodology for separation and structural analysis of impurities in commercially available 7-ethyltryptophol. Several impurity peaks were detected in chromatograms and the structures of major impurities were elucidated by analyzing 1D and 2D LC-NMR spectra.
LC-NMR; impurities; tryptophols
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Podaci o prilogu
440-440.
2015.
objavljeno
Podaci o matičnoj publikaciji
EUROMAR 2015 Programme and Abstract Book
Sklenář, Vladimír
Brno: Masaryk University
978-80-210-7890-1
Podaci o skupu
EUROMAR 2015
poster
05.07.2015-10.07.2015
Prag, Češka Republika