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LC-NMR analysis of impurities in a key starting material of Etodolac (CROSBI ID 626077)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Biljan, Ivana ; Car, Željka ; Jednačak, Tomislav ; Pičuljan, Katarina ; Ribić, Rosana ; Habinovec, Iva ; Galić, Nives ; Tomić, Srđanka ; Novak, Predrag LC-NMR analysis of impurities in a key starting material of Etodolac // EUROMAR 2015 Programme and Abstract Book / Sklenář, Vladimír (ur.). Brno: Masaryk University, 2015. str. 440-440

Podaci o odgovornosti

Biljan, Ivana ; Car, Željka ; Jednačak, Tomislav ; Pičuljan, Katarina ; Ribić, Rosana ; Habinovec, Iva ; Galić, Nives ; Tomić, Srđanka ; Novak, Predrag

engleski

LC-NMR analysis of impurities in a key starting material of Etodolac

Tryptophols are derivatives of 2-(1H-indol-3-yl)ethanol, indole class bearing a C-3 hydroxyethyl side chain. 7-Ethyltryptophol, 2-(7-ethyl-1H-indol-3-yl)ethanol, is a key starting material in the synthesis of Etodolac, an important non-steroidal anti-inflammatory drug. The currently available synthetic procedures for 7-ethyltryptophol usually result with formation of a high-level of various impurities. LC-NMR is a very powerful tool for obtaining detailed structural information of components in complex mixtures such as impurities and metabolites in pharmaceuticals, natural products and synthetic polymers. In the present study, we developed LC-NMR methodology for separation and structural analysis of impurities in commercially available 7-ethyltryptophol. Several impurity peaks were detected in chromatograms and the structures of major impurities were elucidated by analyzing 1D and 2D LC-NMR spectra.

LC-NMR; impurities; tryptophols

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Podaci o prilogu

440-440.

2015.

objavljeno

Podaci o matičnoj publikaciji

EUROMAR 2015 Programme and Abstract Book

Sklenář, Vladimír

Brno: Masaryk University

978-80-210-7890-1

Podaci o skupu

EUROMAR 2015

poster

05.07.2015-10.07.2015

Prag, Češka Republika

Povezanost rada

Kemija