engleski

Biomarkers in exhaled brweath condensate in childern with well controlled asthma

Exhaled breath condensate (EBC) analysis is a non- invasive method for evaluation of a wide range of molecules from the respiratory tract, facilitating the understanding of pathways propagating airway inflammation. High urate levels in EBC may be a marker of oxidative stress and pH of EBC has been found to be lower in many respiratory disorders. Aiming at better understanding of asthma control, we examined their levels in EBCs from children with asthma and children in remission. EBCs were collected from 96 children, aged 5-18 years. Subjects were divided into 4 groups: children with poorly controlled asthma (n=22) ; children with well controlled asthma (n=22) ; children with asthma in remission (n=7) ; non-asthmatic children (n=51). Urate level and pH, as well as urea level as normalization factor, were measured in EBCs. Urea and pH levels in EBC did not differ among different subject groups. Urate levels in EBC were lower in children with well controlled asthma and children with asthma in remission compared to children with poorly controlled asthma, and in children with well controlled asthma compared to non-asthmatic children. Urate level in EBC is a potential biomarker of good asthma control, as well as remission of asthma in children.

Biomarkers ; children ; asthma ; breath condesate

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