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SELF-ASSEMBLY OF TRIPEPTIDE HYDROGELATORS AS A MODEL OF Aβ-PROTEINS AGGREGATION (CROSBI ID 626883)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Pospišil, Tihomir ; Frkanec, Leo ; Žinić, Mladen SELF-ASSEMBLY OF TRIPEPTIDE HYDROGELATORS AS A MODEL OF Aβ-PROTEINS AGGREGATION // XXIV. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka / Š. Ukić ; T. Bolanča (ur.). Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2015. str. 171-171

Podaci o odgovornosti

Pospišil, Tihomir ; Frkanec, Leo ; Žinić, Mladen

engleski

SELF-ASSEMBLY OF TRIPEPTIDE HYDROGELATORS AS A MODEL OF Aβ-PROTEINS AGGREGATION

Alzheimer's disease is characterized by the extracellular fibrillar deposits of the 39-42 amino acid amyloid-β proteins (Aβ). It was shown that the KLVFF fragment of Aβ-peptide is responsible for the formation of amyloid fibrils. The self-assembly phenomena of the low molecular weight peptides into supramolecular gels show resemblance to amyloid-β protein aggregation and hence may serve as a simple model for Aβ-aggregation which could enable design of new aggregation inhibitors. We have synthesized a series of new tripeptide gelators incorporating amino acids present in the Aβ- protein KLVFF fragment denoted responsible for the protein aggregation. Prepared peptides were tested for gelation of water and organic solvents. Organisation in gel assemblies at the supramolecular level and gel morphology was determined by using spectroscopic methods (1HNMR, FTIR) and electronic microscopy (TEM). Tripeptide derivative (Ac-FFA-NH2) was capable to self- assemby into hydrogel at physiological pH. Figure 1 shows possible antiparallel β- sheet hydrogen-bonding motifs of Ac-FFA-NH2 in the hydrogel. The aggregated tripeptide binds with conjugated dyes – Thioflavin T and Congo Red representing common reagents for determining specific amyloid fibrillation.

SELF-ASSEMBLY OF TRIPEPTIDE HYDROGELATORS

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Podaci o prilogu

171-171.

2015.

objavljeno

Podaci o matičnoj publikaciji

XXIV. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka

Š. Ukić ; T. Bolanča

Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)

978-953-6894-54

Podaci o skupu

XXIV. hrvatski skup kemičara i kemijskih inženjera

poster

21.04.2015-24.04.2015

Zagreb, Hrvatska

Povezanost rada

Kemija