Synthesis and X-Ray Studies of Novel 3-C-Nitromethyl-Hexofuranoses (CROSBI ID 221555)
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Podaci o odgovornosti
Turks, M. ; Vēze, K. ; Kiseļovs, G. ; Mackeviča, J. ; Lugiņina, J. ; Mishnev, A. ; Markovic, D.
engleski
Synthesis and X-Ray Studies of Novel 3-C-Nitromethyl-Hexofuranoses
A practical method for the synthesis of three novel 3-C-nitromethyl-hexofuranoses is reported. The Henry reaction on a 1, 2:5, 6-di-O-isopropylidene-α-d-gulofuranose-derived ketone provided a 3-C-branched gulo-isomer as the sole reaction product. The dehydration-rehydration of the latter yielded an isopropylidene-protected 3-C-nitromethyl-galactofuranose. The reaction sequence can be also used for the synthesis of a 3-deoxy-3-C-nitromethyl-hexofuranose derivative with a gulo-configuration. Two of the newly obtained carbohydrate derivatives were characterized by X-ray crystallography.
Synthesis; X-ray studies; 3-C-nitromethyl-hexofuranoses
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