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The Isolation and Synthesis of Neodolastane Diterpenoids (CROSBI ID 221562)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Markovic, Dean ; Kolympadi, M. ; Deguin, B. ; Poree, F.-H. ; Turks, M. The Isolation and Synthesis of Neodolastane Diterpenoids // Natural product reports, 32 (2015), 230-255

Podaci o odgovornosti

Markovic, Dean ; Kolympadi, M. ; Deguin, B. ; Poree, F.-H. ; Turks, M.

engleski

The Isolation and Synthesis of Neodolastane Diterpenoids

The neodolastane diterpenoids comprise a group of 44 compounds including guanacastepenes, heptemerones, plicatilisins, radianspenes, 2, 15-epoxy-5, 13-dihydroxyneodolast-3-en-14-one and sphaerostanol. These fungal and marine natural products are characterized by a tricyclic neodolastane skeleton that consists of fused five-, seven- and six-membered rings. Their reported antibiotic activities against antibiotic-resistant bacteria together with strong antifungal and anticancer activities and their novel structures render these compounds interesting synthetic targets. The aim of this account is to summarise the progress in the isolation, characterisation and synthesis of these diterpenoids as well as to review their biogenetic origins and diverse biological activities since their discovery in 2000.

neodolastanes ; isolation ; synthesis ; biological activities

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Podaci o izdanju

32

2015.

230-255

objavljeno

0265-0568

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