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Assessment of primary DNA damage in organs of Wistar rats after acute exposure to different silver nanoparticles (CROSBI ID 628836)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Milić, Mirta ; Ljubojević, Marija ; Ćurlin, Marija ; Micek, Vedran ; Jurašin, Darija ; Pavičić, Ivan ; Gajović, Srećko ; Vinković Vrček, Ivana Assessment of primary DNA damage in organs of Wistar rats after acute exposure to different silver nanoparticles // Journal of trace elements in medicine and biology / Jurasović, Jasna ; Aschner, Michael (ur.). 2015. str. 26-26

Podaci o odgovornosti

Milić, Mirta ; Ljubojević, Marija ; Ćurlin, Marija ; Micek, Vedran ; Jurašin, Darija ; Pavičić, Ivan ; Gajović, Srećko ; Vinković Vrček, Ivana

engleski

Assessment of primary DNA damage in organs of Wistar rats after acute exposure to different silver nanoparticles

Silver nanoparticles (AgNPs), due to their biocidal activity, are commonly used as a coating or embedding agents for wound dressings, surgical instruments, implants and bone prostheses, odor-resistant textiles, deodorants, room sprays, water cleaners, laundry detergents, in food packaging and wall paints. The increasing use of nanosilver-containing products poses toxicological and environmental issues which need to be addressed. Here, we present results on primary DNA damage in blood, kidney and liver of 3 months old male and female Wistar rats after 30 min exposure to 1 mg/kg b.w. of silver nanoparticles (AgNPs). Comparison was done for effects of 3 types of AgNPs coated with polyvinylpyrrolidone (PVPAgNPs), metallothionein (METAgNPs), and bovine serum albumin (BSAAgNPs). Tail length, tail intensity (TI) and tail moment were measured by the alkaline comet assay. All experiments were performed in triplicate. In total, 300 comets per concentration were measured. Statistical analysis was performed for TI as recommended by OECD for in vivo genotoxicity testing of chemicals. In the female group, significantly higher DNA damage compared to controls was seen in blood and liver for all AgNPs types, while in kidney samples only BSAAgNPs treatment induced significantly higher TI. In male group, only liver showed significantly higher TI than controls for all three types of AgNPs. In male blood, only METAgNPs induced significant DNA damage compared to controls, while kidneys of males treated with PVPAgNPs and BSAAgNPs showed significantly lower TI values than controls. Since the physicochemical properties of AgNPs such as particle size, surface charge, surface functionalization, and dispersibility significantly influence the degree and actions of AgNPs, further research is required to assess the effects of these variables on their toxicity.

silver nanoparticles ; genotoxicity ; Wistra rat ; Comet assay

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Podaci o prilogu

26-26.

2015.

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objavljeno

Podaci o matičnoj publikaciji

Journal of trace elements in medicine and biology

Jurasović, Jasna ; Aschner, Michael

Amsterdam: Elsevier

0946-672X

Podaci o skupu

ISTERH Conference Recent Advances in Trace Element Research in Health and Disease (11 ; 2015)

poster

18.10.2015-22.10.2015

Srebreno, Hrvatska

Povezanost rada

Biologija, Javno zdravstvo i zdravstvena zaštita, Kemija

Indeksiranost