Metallothionein expression in mercury-exposed suckling rats and detoxification with selenium (CROSBI ID 628944)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Lazarus, Maja ; Orct, Tatjana ; Ljubojević, Marija ; Sekovanić, Ankica ; Jurasović, Jasna ; Sabolić, Ivan
engleski
Metallothionein expression in mercury-exposed suckling rats and detoxification with selenium
Selenium (Se) supplementation has been shown to change the distribution and excretion of mercury (Hg) in suckling rats exposed to inorganic Hg. The effect of exogenous Se on the level and role of Hg-induced metallothionein (MT) expression in young animals has not yet been studied. Seven- day-old Wistar pups were orally pre-treated with Se (6 μmol Na2SeO3/kg b.w.) for 3 days, and then co-treated with Hg (6 μmol HgCl2/kg b.w.) for the following 4 days. This group (Se+Hg) was compared to groups treated with Hg or Se alone, or with a vehicle (Control). Immunoblotting analyses revealed strong MT expression in the kidney (P<0.001), but not in the liver of Hg-exposed rats. Hepatic MT was stimulated by Se treatment in Se and Se+Hg groups. Renal MT expression was lower in Se- supplemented rats exposed to Hg compared to the Hg-only group. Our study in suckling rats confirmed earlier results for adult animals, and indicated that the binding of Hg to selenoproteins may form an inert complex that cannot induce MT.
mercury exposure; metallothionein; selenium; suckling rat
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
S22-x.
2015.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Journal of trace elements in medicine and biology
Jurasović, Jasna ; Aschner, Michael
Elsevier
0946-672X
Podaci o skupu
XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease
predavanje
18.10.2015-22.10.2015
Srebreno, Hrvatska
Povezanost rada
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita