engleski

Gallic acid reduces tumor growth and angiogenesis in mice with Ehrlich ascites tumor

Gallic acid, also known as 3, 4, 5 trihydroxybenzoic acid, is a type of phenolic acid, which is present in plants worldwide, including Croatian medicinal herbs. Gallic acid has been shown to have cytotoxic effects in certain cancer cells, without damaging normal cells. The objective of the present study was to determine whether gallic acid is able to inhibit growth of Ehrlich ascites tumor (EAT) in mice. EAT cells (2.5x106) were implanted intraperitoneally (i.p.) in Swiss albino mice. One day after tumor inoculation, mice were injected i.p. with GA at dose of 40 and 80 mg kg‐1 bw during 10 days. On day 14, ascites volume, the total number of cells in the peritoneal cavity, microvessel density, functional activity of macrophages and nitric oxid production (NO) were determined. GA therapy normalizes VEGF in ascites and decreases neoangiogenesis, thereby reducing tumor growth and im proving survival. GA‐ treated animals at dose of 40 mg kg‐1 developed ascites in a smaller volume compared to the control, suggesting decreased vascular permeability by reducing VEGF expression in EAT cells.

gallic acid ; tumor growth ; angiogenesis ; VEGF

nije evidentirano