engleski

The effectiveness of quercetin on biomarkers for osteoporosis

Oxidative stress may lead to extensive bone loss and skeletal fragility, two characteristics of osteoporosis. We studied the bone‐protective effect of quercetin (QU) in the retinoic acid induced model of osteoporosis (RMO) and in healthy rats. Densitometry, osteocalcin (OC), Cterminal cross‐linked telopeptide (CTX), calcium (Ca) and phosphorus (P) content of bone femur, geometric measurement on the femur, histology, hematological and biochemical parameters as well as lipid peroxidation (MDA) and glutathione levels (GSH) of liver and kidney cells were applied to all groups. Retinoic acid administration (80 mg kg‐1) revealed significant increase in biochemical parameters, MDA level, OC and CTX values and a significant decrease in values of BMD, Ca and P in the femur and GSH levels in liver and kidney compared to control. Administration of QU intragastrically (100 mg kg‐1 bw) daily concomitant with retinoic acid resulted in significantly reduction of CTX values and MDA in comparison to RMO. QU also exerted positive effects on biochemical parameters, values of Ca and P, BMD values in distal part, femoral weight and length and the GSH level. Concomitant treatments of rats with retinoic acid and alendronate had toxic effect to animals and resulted in a significant decrease in body mass of 5.67% after two weeks. The protective role of the QU against the toxicity of retinoic acid‐induced osteoporosis in rats gives a hope that QU may have similar protective action in humans.

retinoic acid ; osteoporosis ; quercetin ; alendronate ; rat

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