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Effect of flavonoids and hyperthermal intraperitoneal chemotherapy (HIPEC) on tumour growth and micronucleus induction in mouse tumour model

Hyperthermia enhanced the clastogenicity of alkylating agents. We investigated whether quercetin (QU) or naringenin (NAR) can sensitize Ehrlich ascites tumour to cisplatin hyperthermal intraperitoneal chemotherapy (HIPEC) treatment and whether these flavonoids in combination with cisplatin can ameliorate cisplatin‐induced micronuclei in peripheral blood reticulocytes of mice. QU or NAR were administered to mice 7 and 3 days before implantation of EAT cells, while cisplatin (5 or 10 mg kg‐1) was injected intraperitoneally to normothermic or hyperthermic‐treated mice 3 days after implantation of EAT cells (2×106). Our study supports the claim that the QU or NAR in combined treatment with cisplatin has the potential to inhibit tumour growth in both normothermic and hyperthermic conditions and attenuate number of micronuclei in the peripheral blood reticulocytes of mice at normothermic condition but enhanced the clastogenicity of cisplatin agents in hyperthermal condition.

hyperthermia ; chemotherapy ; flavonoids ; Ehrlich ascites tumour ; genotoxicity

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