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Protective and reparative effect of pentadecapeptide BPC 157 on mice blood, liver and kidney cells (CROSBI ID 629567)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Oršolić, Nada ; Kunštić, Martina ; Kukolj, Marina ; Sirovina, Damir ; Šopf, Ivan Protective and reparative effect of pentadecapeptide BPC 157 on mice blood, liver and kidney cells // Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem) / Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija et al. (ur.). Zagreb, 2015. str. 268.-269

Podaci o odgovornosti

Oršolić, Nada ; Kunštić, Martina ; Kukolj, Marina ; Sirovina, Damir ; Šopf, Ivan

engleski

Protective and reparative effect of pentadecapeptide BPC 157 on mice blood, liver and kidney cells

We investigated the protective and reparative effect of BPC 157 on blood, liver and kidney cells of mouse, after cisplatin (CP) treatment. The mice were divided into 4 groups: control, BPC 157, BPC 157 and CP and CP. We monitored the levels of DNA damage in blood, liver and kidney cells after 0, 1, 6, and 24 h and the speed of DNA repair. The comet test shows that the DNA was mostly damaged by CP after 1 h in all analysed tissues and the % of damage was visible after 24 h, which indicated a large number of double‐strand breaks. The highest number of apoptotic cells was found in kidney cells. BPC 157 caused the DNA damage after 1 and 6 h as a result of oxidative stress incurred by BPC 157 administration. The values returned to normal after 24 h. The combined treatment with BPC 157 and CP resulted in lower CP‐caused DNA damage. A number of micronuclei, which is a double‐strand break indicator, in the CP group increased proportionally to the period of exposure and had the highest value after 24 h. The combined treatment with BPC and CP decreased the micronuclei count. It was shown that the most sensitive organ to the toxic effects of CP was the kidney, followed by liver and lymphocytes. Results indicated that BPC 157 has a protective effect on healthy cells, which is possibly based on a reduced intake of CP into the cell or BPC 157 participation in the process of DNA‐repair in damaged cells, which requires further research.

cisplatin ; BPC 157 ; mouse ; micronucleus test ; comet test

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

268.-269..

2015.

objavljeno

Podaci o matičnoj publikaciji

Zbornik sažetaka (12. Hrvatski biološki kongres s međunarodnim sudjelovanjem)

Klobučar, Göran ; Kopjar, Nevenka ; Gligora Udovič, Marija ; Lukša, Žaklin ; Jelić, Dušan

Zagreb:

Podaci o skupu

"12. Hrvatski biološki kongres s međunarodnim sudjelovanjem"

poster

18.09.2015-23.09.2015

Sveti Martin na Muri, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Farmacija, Biologija