engleski

Quercetin attenuates n‐hexyl salicylate or di‐ n‐propyl disulfide‐induced skin irritation: oxidative stress and inflammation

This study examined the possible positive effects of quercetin on animal model of psoriasis, induced by the Hexyl salicylate or Di‐n‐Propyl Disulfide irritant (PPD). Furthermore, we evaluated the usefulness of thermography in psoriatic lesion regression. We monitored the inflammation process by histopathological assessment of skin, thermographic scanning, total number of inflammatory cells in peritoneal cavity, differential analysis of cells in peritoneal cavity, macrophage spreading index, hematological and biochemical parameters, frequencies of micronucleated reticulocytes, lipid peroxidation and glutathione assay in skin, liver and kidney. Topically applied quercetin with HXS or PPD may improve psoriatic‐like skin lesions by suppressing number of inflammatory cells in skin, functional activity of macrophages, and ROS production. In addition, total number of inflammatory cells in peritoneal cavity, macrophage spreading index, lipid peroxidation in liver and kidney, and enzymatic activity of ALP and AST were reduced in psoriatic mice treated with quercetin. Taken together, these results support the quercetin as an antiinflammatory and antioxidative agent and open up new possibilities for its use in skin disorders without causing any toxic effect. Thermography as a method can be applicable in examining of the inflammatory process in psoriasis and in evaluating the effectiveness of quercetin and other tested substances.

mouse models of psoriasis ; skin lesions ; quercetin ; thermography

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