engleski

Influence of the Inherited Glucose-6-phosphate Dehydrogenase Deficiency on the Appearance of Neonatal Hyperbilirubinemia in Southern Croatia.

Background: Neonatal hyperbilirubinemia is a common clinical manifestation of the inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency. Aim of the study: The aim of this study was to investigate the inflence of the inherited G6PD deficiency on the appearance of neonatal hyperbilirubinemia in southern Croatia. Methods: The florescent spot test (FST) was used in a retrospective study to screen blood samples of 513 male children who had neonatal hyperbilirubinemia, of unknown cause, higher than 240 µmol/L. Fluorescence readings were performed at the beginning and at the fith and tenth minute of incubation and were classifid into three groups: bright florescence (BF), weak florescence (WF) and no florescence (NF). Normal samples show bright florescence. All NF and WF samples at the fith minute were quantitatively measured using the spectrophotometric method. Results: Bright florescence was present in 461 patients (89.9%) at the fith minute. The remaining 52 (10.1%) were quantitatively estimated using the spectrophotometric method. G6PD defiiency was observed in 38 patients (7.4%). Conclusions: Prevalence rate of G6PD defiiency among male newborns with hyperbilirubinemia in southern Croatia is signifiantly higher (p < 0.01) compared with the previously reported prevalence rate among male in general population of southern Croatia (0.75%). We recommend FST to be performed in hyperbilirubinemic newborns in southern Croatia

G6PD deficiency; neonatal hyperbilirubinemia; florescent spot test

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