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Evaluation and Management of Neonatal Indirect Hyperbilirubinaemia at the University Pediatric Clinic in Skopje, Republic of Macedonia (CROSBI ID 222385)

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Papazovska Cherepnalkovski, Anet ; Piperkova, Katica ; Palčevska, Kočevska ; Aluloska, N ; Zdraveska, N ; Gruev, Todor ; Krželj, Vjekoslav Evaluation and Management of Neonatal Indirect Hyperbilirubinaemia at the University Pediatric Clinic in Skopje, Republic of Macedonia // Medicus (Tetovë), 20 (2015), 2; 221-119

Podaci o odgovornosti

Papazovska Cherepnalkovski, Anet ; Piperkova, Katica ; Palčevska, Kočevska ; Aluloska, N ; Zdraveska, N ; Gruev, Todor ; Krželj, Vjekoslav

engleski

Evaluation and Management of Neonatal Indirect Hyperbilirubinaemia at the University Pediatric Clinic in Skopje, Republic of Macedonia

Introduction: Neonatal hyperbilirubinemia, defined as a total serum bilirubin level > 86 μmol/L, is a frequent problem affecting approximately 60% of term and 80% of preterm newborns. Clinical challenge is to differentiate between the majority of physiologically jaundiced infants and those with pathological causes, thus to establish appropriate management plan. Objectives: Purpose of the study was to review evaluation and management of neonatal indirect hyperbilirubinemia at the University Pediatric Clinic Neonatology Department over a two year period. Methods: Medical records of 284 newborns with indirect hyperbilirubinemia were retrospectively analyzed for history data, clinical presentation, diagnostic procedure and the therapy applied. Results: Most prevalent was jaundice of undefined etiology (44.37%), followed by neonatal infection, prematurity, hemolysis, and birth trauma. The mean peak serum bilirubin concentration in the undefined etiology group was 333.4±91.1 μmol/l. The peak bilirubin levels and reticulocites in hemolytic jaundice were significantly higher compared to the other etiologies. The fist control serum bilirubin level was significantly higher in newborns with hemolysis compared to the groups of premature newborns and jaundice of undefined etiology. Analyzed groups significantly differed according to the day bilirubin reached peak. Most cases were treated with phototherapy, and 2.11% with exchange transfusion. Conclusions: Hyperbilirubinemia is a frequent pathology at the University Pediatric Clinic- Skopje, R. Macedonia. Most cases are treated with less severe jaundice of undefined etiology. Immediate awareness and management is required for those 15% of infants with hemolytic causes of jaundice that carry a significant risk for early and severe hyperbilirubinemia.

hyperbilirubinemia; neonate; ABO incompatibility; sepsis; prematurity; G6PD defiiency; evaluation and management; Republic of Macedonia

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Podaci o izdanju

20 (2)

2015.

221-119

objavljeno

1409-6366

Povezanost rada

Kliničke medicinske znanosti