The effect of metal exposure and metallothionein 2A gene polymorphism on levels of toxic and essential trace elements at childbirth (CROSBI ID 629732)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Sekovanić, Ankica ; Jurasović, Jasna ; Pašalić, Daria ; Piasek, Martina
engleski
The effect of metal exposure and metallothionein 2A gene polymorphism on levels of toxic and essential trace elements at childbirth
Increased levels of toxic metals in maternal organism may interfere with transplacental essential element transport to the fetus. We analyzed toxic (Cd, Pb) and essential trace elements (Zn, Cu, Fe, Se) in maternal blood, cord blood and placenta and MT2 polymorphism (rs28366003) in two cohorts of postpartum women who gave birth in maternity hospitals in continental and coastal Croatia (in total N=280). Increased levels of both Cd and Pb were found in maternal blood and placenta due to cigarette smoking. Differences in regional exposure and lifestyle contribute to the increased placental Cd in coastal area. Higher levels of Zn in the placenta of smokers were most probably due to Cd- induced increased MT synthesis in the placental cells making Zn less available to the fetus. In smokers were also increased Cu in umbilical cord blood. No associations were found between MT2A gene polymorphism and trace elements in maternal and umbilical cord blood and placenta. In conclusion, increased toxic metal exposure of expectant mother rather than specific MT2A individual genetic susceptibility is associated with disrupted transplacental essential element transfer that may put at risk fetal growth and development.
metal exposure; MT2A gene polymorphism; trace elements
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Podaci o prilogu
S33-x.
2015.
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objavljeno
Podaci o matičnoj publikaciji
Journal of trace elements in medicine and biology
Jurasović, Jasna ; Aschner, Michael
Elsevier
0946-672X
Podaci o skupu
Abstracts XI ISTERH Conference Recent Advances in Trace Element Research in Health and Disease
poster
18.10.2015-22.10.2015
Srebreno, Hrvatska
Povezanost rada
Javno zdravstvo i zdravstvena zaštita