engleski

Effect of mandibular advancement device therapy on cognitive and psychomotor performance in obstructive sleep apnea

Background. Obstructive sleep apnea (OSA) is common sleep-disordered breathing characterized by recurrent episodes of upper airway collapse during sleep with associated airflow obstruction, intermittent hypoxemia, sympathetic excitation and sleep fragmentation. Intermittent hypoxemia and sleep fragmentation may contribute to impaired cognitive and psychomotor performance. Aims. The aim of this study was to determine the effect of the custommade adjustable mandibular advancement device (MAD) on cognitive and psychomotor performance in patients with mild to moderate OSA. Methods. A total of 15 patients with mild to moderate OSA were treated with custom-made adjustable MAD and they were followed-up after 1 year of therapy. Sleep studies were performed with and without the MAD. The patients were tested on three different tests of cognitive and psychomotor performance using computer-based system Complex Reactionmeter Drenovac (CRD series) at baseline and at the time of follow-up. Results. The mean apnea-hypopnea index (AHI) decreased significantly from 22.9±5.9 at baseline, to 9.7±4.5 after 1 year of therapy (p<0.001). Total test solving time (TTST) on simple arithmetic operation test was significantly shorter following MAD therapy (155.36±60.82 to 137.09±0.48 s, p=0.026) and reaction time to light signal position test (36.72±5.34 to 33.89±4.55 s, p=0.011). There was no significant change in TTST on arms/legs motor coordination test. Conclusions. This study demonstrates significant improvements in some aspects of cognitive and psychomotor performance in mild to moderate OSA patients following MAD therapy.

mandibular advancement device therapy; cognitive; psychomotor; obstructive sleep apnea

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