engleski

Causes and treatment of habitual abortion

Spontaneous abortion is undesired pregnancy loss of a fetus weighing less than 500 g before the 22nd week of gestation, classifi ed into sporadic and recurrent according to its occurrence. In case of two or more consecutive pregnancy losses, it is referred to as habitual abortion. Habitual abortions cause a serious problem in women who fail to carry their pregnancies to the term necessary for the fetus to survive. Habitual abortions generally occur in the same period of gestation. There are numerous causes of habitual abortions, including genetic factors, uterine anomalies, thrombophilias, endocrinopathies (corpus luteum insuffi ciency, diabetes mellitus, thyroid diseases, etc.), immune disorders, male factor, and environmental factors. The basic clinical workup in couples with a history of habitual abortion includes thorough personal and family history, maternal complete blood count and thyroid function tests, laboratory testing for antiphospholipid antibodies and gynecologic examination, and karyotyping in both partners. Habitual abortions are recorded in 1% of reproductive couples, while the cause of miscarriage remains unknown in about 50% of cases. In case of identifi ed pathology, treatment is only possible in the group of non-genetic etiology. This review article presents current diagnostic options to identify the cause and to treat patients with habitual abortions.

habitual abortion; cause; treatment

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