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Pregled bibliografske jedinice broj: 790223

Zbornik radova

Autori: Babić Leko, Mirjana; Borovečki, Fran; Jurasović, Jasna; Orct, Tatjana; Hof, Patrick R.; Šimić, Goran
Naslov: Levels of cerebrospinal fluid macro and microelements in mild cognitive impairment patients with and without pathological levels of six Alzheimer’s disease protein biomarkers
Izvornik: Book of abstracts of the 5th Croatian Neuroscience Congress
Skup: 5th Croatian Neuroscience Congress
Mjesto i datum: Split, Hrvatska, 17-19.09.2015.
Ključne riječi: Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements
Sažetak:
Objective: Alzheimer's disease (AD) is the major primary cause of dementia. Mild cognitive impairment (MCI) is a syndrome characterized by cognitive impairment without dementia. About 10% MCI patients have an initial stage of AD. There is an urgent need for detection of novel CSF biomarkers that would improve early diagnosis of AD. As homeostasis of macro and microelements is disturbed in the AD brain, measurement of macro and microelements’ levels in the cerebrospinal fluid (CSF) has a diagnostic potential in identification of MCI patients who will progress to AD. The main goal of this study was to differentiate two groups of MCI patients (with and without pathological levels of AD protein biomarkers, altogether 31 MCI patients) by using concentrations of 24 macro and microelements measured in CSF (Li, B, Na, Mg, Al, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Pb, and Hg). Methods: Six AD protein biomarkers (Aβ1-42, t- tau, p-tau181, p-tau199, p-tau231 and VILIP-1) were measured using ELISA, while CSF macro and microelements were measured using inductively coupled plasma mass spectroscopy (ICP-MS). Results: Levels of S, Co, Mo, and Tl were significantly increased in the MCI group with pathological Aβ1-42 levels, while levels of K, Cr, Fe, Cu, As, Se, and Hg were significantly increased in the MCI group with pathological p- tau181 levels. Significant increase in Ca and As levels was found in the MCI group with pathological p-tau199 levels, while the MCI group with pathological p-tau231 levels had increased concentrations of Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, and Hg. The MCI group with pathological VILIP-1 levels had significantly higher levels of Na, Mg, S, K, Ca, Cr, Fe, Mn, Cu, As, Se, Sr, Ba, and Hg. Conclusions: Despite being preliminary and obtained from a relatively small cohort of MCI patients, these results indicate that macro and microelements can be potentially used as diagnostic markers of disease progression. The most probable CSF metals biomarkers are Hg, K, Cr, Fe, S, Cu, As and Se, since their levels were increased in MCI groups with even three pathological protein biomarkers.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1942, HRZZ-09/16, IP-2014-09-9730
Izvorni jezik: ENG
Kategorija: Ostalo
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Goran Šimić (gsimic@hiim.hr), 15. Pro. 2015. u 17:22 sati



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