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Pregled bibliografske jedinice broj: 790225

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Autori: Babić Leko, Mirjana; Borovečki, Fran; Jurasović, Jasna; Orct, Tatjana; Hof, Patrick R.; Šimić, Goran
Naslov: Macro and microelements and Alzheimer’s disease protein biomarkers in cerebrospinal fluid
Izvornik: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY / Jurasović, Jasna ; Aschner, Michael (ur.). - Elsevier GmbH , 2015. 7-7.
ISSN: 0946-672X
Skup: Recent Advances in Trace Element Research in Health and Disease
Mjesto i datum: Srebreno, Hrvatska, 18-22.10.2015.
Ključne riječi: Alzheimer's disease; mild cognitive impairment; biomarkers; cerebrospinal fluid; macro and microelements
Sažetak:
The homeostasis of macro and microelements is altered in the brain of patients suffering from Alzheimer’s disease (AD). In this study we analysed 24 macro and microelements in cerebrospinal fluid (CSF) and correlated its concentration with AD protein biomarkers (Aβ1- 42, t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1) in CSF of 63 patients with AD, 31 with mild cognitive impairment (MCI), and 11 healthy controls (HC). A significantly negative correlation was found between Aβ1-42 and Co, while significantly positive correlations were obtained between t-tau and Li, As, Se, Sr ; p- tau181 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Mo, Tl, Hg ; p-tau199 and B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Cu, As, Se, Sr, Mo, Cd, Ba, Tl, Hg ; p-tau231 and Li, B, Na, Mg, S, K, Cr, Fe, Co, Mn, Ni, Cu, Zn, Se, Sr, Mo, Tl, Hg ; VILIP-1 and Li, B, Na, Mg, S, K, Ca, Cr, Fe, Co, Mn, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Tl, Hg. Although possible explanation of altered levels of elements in AD brain will await identification of their environmental sources or detection of their release from brain tissue due to cell death, these results suggest CSF element analysis potential as marker of AD neurodegenerative process.
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Web of Science: Science Citation Index Expanded
Scopus
Current Contents Citation Index
MEDLINE
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: IP-2014-09-9730, HRZZ-09/16, 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Goran Šimić (gsimic@hiim.hr), 15. Pro. 2015. u 17:36 sati



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