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Pregled bibliografske jedinice broj: 790359

Zbornik radova

Autori: Knezović, Ana; Šimić, Goran; Šalković-Petrišić, Melita
Naslov: TIME-COURSE OF ASTROGLIAL CHANGES AND COGNITIVE DECLINE IN A RAT MODEL OF SPORADIC ALZHEIMER’S DISEASE
Izvornik: Neurologia Croatica / Šimić, Goran ; Mimica, Ninoslav (ur.). - Zagreb : Denona d.o.o. , 2014. 79-79.
Skup: Croatian Congress on Alzheimer’s Disease (CROCAD- 14) with International Participation
Mjesto i datum: Brela, Hrvatska, 01-04.10.2014.
Ključne riječi: Alzheimer’s disease; Streptozotocin; Amyloid protein; Tau protein; Lysosomes; Cognitive decline
Sažetak:
Objectives: Cognitive decline is a major behavioural hallmark and astrogliosis is a characteristic neuropathological feature of sporadic Alzheimer’s disease (sAD). Central administration of streptozotocin (STZicv) is shown to induce both these Alzheimer-like changes in rats due to STZ-icv rat model has been proposed as ananimal model of sAD. We have investigated the 9-month time course of cognitive decline and astrogliosis induced by 3 STZ-icv doses in this rat sAD model. Methods: Male 3 month-old Wistar rats were icv injected by STZ- (0.3, 1 and 3 mg/kg dose) or vehicle (controls) and sacrificed one, three, six or nine months after the treatment. Cognitive functions were tested by Passive Avoidance Test before sacrifice. Paraffinembedded brain sections were immunohistochemically stained for detection of glial fibrillary acidic protein (GFAP) signal and analysed with cellSense Dimenson software. Data were analysed by Kruskal-Wallis and Mann-Whitney U test (p<0.05). Results: STZ-icv rat model demonstrated dose- and timedependent cognitive deficits, pronounced with higher doses with acute decline after 1 month (-90%) and progressive one after 6 - 9 months (-45% to -90%). Higher STZ doses increased (+45%) the expression of GFAP positive cells acutely after 1 month, decreased (-63%) it after 6 months and then increased it (+35%) again 9 months following STZ administration. Conclusion: Results suggest that both cognitive deficit and astrogliosis induced by higher STZ- icv doses, demonstrate a biphasic pattern of appearance ; acute changes found after1 month and chronic (progressive) ones found 6-9 months after the treatment. Supported by UKF and MZOS.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1942, HRZZ-09/16
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Goran Šimić (gsimic@hiim.hr), 16. Pro. 2015. u 12:24 sati



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