Photogeneration of quinone methides in supramolecular complexes: Potential for new drug delivery (CROSBI ID 632572)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Škalamera, Đani ; Bohne, Cornelia ; Landgraf, Stephan ; Basarić, Nikola
engleski
Photogeneration of quinone methides in supramolecular complexes: Potential for new drug delivery
Quinone methides (QM) are commonly encountered reactive intermediates in chemistry and photochemistry of phenols, particularly interesting due to their biological activity.[1] Appropriately substituted bifunctional QMs cross-link DNA or peptides and proteins, which leads to disruption of cell maintenance and replication. Moreover, some QMs are reactive intermediates responsible for the action of antibiotics for anticancer therapy.[2] In a recent publication we have reported mechanistic details on the photochemical deamination of Mannich salts 1 and 2 that deliver long-lived QMs.[3] Preliminary antiproliferative investigation of 1 and 2 showed that compounds exhibit no enhancement of antiproliferative effect on irradiation of cancer cells. The objective of the current research is to show that 1 and 2 form inclusion complexes with cucurbit[n]urils (CB[n]s) which might facilitate their transport through cell membranes. Therefore, photochemical formation of QMs in a CB[n] complex and subsequent dissociation can have potential to be developed into a new drug delivery method.
quinone methides ; photodeamination ; cucurbit[n]urils ; supramolecular complexes ; cross-linking DNA
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
2016.
objavljeno
Podaci o matičnoj publikaciji
CECP 2016 / Central European Conference on Photochemistry - Bad Hofgastein, Austria
Podaci o skupu
CECP 2016 / Central European Conference on Photochemistry
poster
14.02.2016-18.02.2016
Bad Hofgastein, Austrija