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Photogeneration of quinone methides in supramolecular complexes: Potential for new drug delivery (CROSBI ID 632572)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Škalamera, Đani ; Bohne, Cornelia ; Landgraf, Stephan ; Basarić, Nikola Photogeneration of quinone methides in supramolecular complexes: Potential for new drug delivery // CECP 2016 / Central European Conference on Photochemistry - Bad Hofgastein, Austria. 2016

Podaci o odgovornosti

Škalamera, Đani ; Bohne, Cornelia ; Landgraf, Stephan ; Basarić, Nikola

engleski

Photogeneration of quinone methides in supramolecular complexes: Potential for new drug delivery

Quinone methides (QM) are commonly encountered reactive intermediates in chemistry and photochemistry of phenols, particularly interesting due to their biological activity.[1] Appropriately substituted bifunctional QMs cross-link DNA or peptides and proteins, which leads to disruption of cell maintenance and replication. Moreover, some QMs are reactive intermediates responsible for the action of antibiotics for anticancer therapy.[2] In a recent publication we have reported mechanistic details on the photochemical deamination of Mannich salts 1 and 2 that deliver long-lived QMs.[3] Preliminary antiproliferative investigation of 1 and 2 showed that compounds exhibit no enhancement of antiproliferative effect on irradiation of cancer cells. The objective of the current research is to show that 1 and 2 form inclusion complexes with cucurbit[n]urils (CB[n]s) which might facilitate their transport through cell membranes. Therefore, photochemical formation of QMs in a CB[n] complex and subsequent dissociation can have potential to be developed into a new drug delivery method.

quinone methides ; photodeamination ; cucurbit[n]urils ; supramolecular complexes ; cross-linking DNA

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Podaci o prilogu

2016.

objavljeno

Podaci o matičnoj publikaciji

CECP 2016 / Central European Conference on Photochemistry - Bad Hofgastein, Austria

Podaci o skupu

CECP 2016 / Central European Conference on Photochemistry

poster

14.02.2016-18.02.2016

Bad Hofgastein, Austrija

Povezanost rada

Kemija

Poveznice