engleski

Adverese effects of naringenin, quercetin, chrysin and caffeic acid on lipids in mice on a high fat diet

Polyphenolic compounds naringenin, quercetin, chrysin and caffeic acid are potent natural antioxidants and active compounds of propolis. Lipids are thus transferred in blood as lipoprotein complexes of lipids and apolipoproteins. They are classified according to size, density, and lipid - apolipoprotein ratio: chylomicrons, very low density lipoprotein (VLDL), low density lipoproteins (LDL), intermediate density lipoproteins (IDL) and high density lipoproteins (HDL). Large amounts of LDL are not absorbed in the liver and consumed by macrophages, so they accumulate in the blood stream causing oxidative stress and many pathological conditions. Polyphenolic compounds are alleged antioxidants. In this study we studied the possible antioxidant effects of five polyphenols on the composition of serum and liver lipids in mice on high-fat diet. The naringenin, quercetin, chrysin and caffeic acid were given orally to mice at dose of 50 mg/kg/bw every 48 h, for 30 days. At the end of the treatment serum total triglyceride, cholesterol, HDL, LDL, serum enzymes and metabolites (AST, ALT, ALP i LDH), liver enzymes (MDH and CAT) and MDA product of lipid peroxidation were measured. Results sow that quercetin, chrysin and caffeic acid increased the “bad” and decreased “good” cholesterol in serum probably as a result of slight but significant hepatotoxic effects. On the contrary, no adverse effects reported naringenin.

cholesterol ; oxidative stress ; lipid peroxidation ; propolis

nije evidentirano