Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

The Effectiveness of Quercetin on Biomarkers for Osteoporosis (CROSBI ID 55741)

Prilog u knjizi | izvorni znanstveni rad

Oršolić, Nada ; Goluža, Eleonora ; Jazvinšćak Jembrek, Maja The Effectiveness of Quercetin on Biomarkers for Osteoporosis // Quercetin: Food Sources, Antioxidant Properties and Health Effects / Malone, Gregory (ur.). New York (NY): Nova Science Publishers, 2015. str. 133-160

Podaci o odgovornosti

Oršolić, Nada ; Goluža, Eleonora ; Jazvinšćak Jembrek, Maja

engleski

The Effectiveness of Quercetin on Biomarkers for Osteoporosis

Oxidative stress may lead to extensive bone loss and skeletal fragility, two characteristics of osteoporosis. We studied the bone-protective effect of quercetin in the retinoic acid- induced model of osteoporosis (RMO) and in healthy rats. Densitometry, osteocalcin (OC), C-terminal cross-linked telopeptide (CTX), calcium and phosphorus content of bone femur, femoral geometric measurementsgeometric measurement on the femur, histology, hematological and biochemical parameters, as well as lipid peroxidation (MDA) and glutathione levels (GSH) of liver and kidney cells, were measured in applied to all groups. Retinoic acid administration (80 mg kg-1) revealedinduced a significant increase in biochemical parameters, MDA level, OC and CTX values, and a significant decrease in values of bone mineral density (BMD), Ca and P in the femur, and GSH levels in liver and kidney compared to control. Administration of quercetin intragastrically (100 mg kg-1 b. w. intragastrically, once daily) daily concomitant with retinoic acid resulted in significantly reduction of reduced CTX values and MDA in comparison to RMO, and QU exerted positive effects on biochemical parameters, values of Ca and P, BMD values in distal part, femoral weight and length, and the GSH level. Concomitant treatments of rats with retinoic acid and alendronate, a drug used to treat osteoporosis, had toxic effect to animals and resulted in a significant decrease in body mass of 5.67% after two weeks. The protective role of the quercetin against the toxicity of retinoic acid-induced osteoporosis in rats givesing a hope that quercetin may have similar protective action in humans.

retinoic acid ; osteoporosis ; quercetin ; alendronate ; rat

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

133-160.

objavljeno

Podaci o knjizi

Quercetin: Food Sources, Antioxidant Properties and Health Effects

Malone, Gregory

New York (NY): Nova Science Publishers

2015.

978-1-63483-595-4

Povezanost rada

Temeljne medicinske znanosti