engleski

Global sensitivity analysis of the biological part of the integrated BTEX bioremediation model

The greatest challenge when working with mathematical models describing biological processes is to choose the appropriate values of the kinetic parameters. This applies especially to the models of environmental biological processes, such as bioremediation. Parameter values are usually obtained from various sources and under specific experimental conditions, and constitute sources of uncertainties. A useful tool for dealing with model parameter uncertainties is sensitivity analysis. It studies how a given model depends on its input factors. In this work, the non-stationary Extended Fourier Amplitude Sensitivity analysis was used to analyse the effect of 28 kinetic parameters on 18 metabolite concentrations and 16 reaction rates of the biological part of the integrated BTEX bioremediation model. First-order sensitivities and total effect indices were estimated for three time points of the process in order to identify the places of the metabolism control shift. The analysis revealed that the model is non-additive, and there are no strong interactions between the parameters. The results of this study indicate the importance of using the global sensitivity analysis prior to bioremediation process planning.

Extended-FAST ; global sensitivity analysis ; bioremediation modelling ; BTEX

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