engleski

Scaffold-Free Endogenous Healing of the Articular Cartilage Lesion

The regeneration of the joint cartilage remains a major challenge in medicine, because the factors initiating cartilage formation, maturation, and healing are poorly understood. The ideal outcome of the joint cartilage repair is a restoration of columnar architecture and composition of articular joint hyaline cartilage. The field of tissue engineering (TE) has emerged over the past decades to improve the treatments for tissue and organ failure. TE can be broadly defined as a structural and functional reconstitution of mammalian tissues where the cells, biomaterials, and biological cues are combined. The development of a construct without an artificial scaffold is one of the main concepts of TE technology. A novel tissue-engineering technique has been recently developed for cartilage repair using a scaffold-free tissue-engineered construct (TEC) biosynthesized from allogeneic synovial MSCs.

cartilage, regeneration, autologous, mesenchymal stem cells, tissue engineering, scaffold free

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