Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling (CROSBI ID 226989)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Benn, A ; Bredow, C ; Casanova, I ; Vukicevic, Slobodan ; Knaus, P VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling // Journal of cell science, 129 (2016), 1; 206-218. doi: 10.1242/jcs.179960

Podaci o odgovornosti

Benn, A ; Bredow, C ; Casanova, I ; Vukicevic, Slobodan ; Knaus, P

engleski

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling

Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling. Vascular hyperpermeability via distortion of endothelial cell adherens junctions is a common feature of these diseases, but the role of BMPs in this process has not been investigated. BMP signaling is initiated by binding of ligand to, and activation of, BMP type I (BMPRI) and type II (BMPRII) receptors. Internalization of VE- cadherin as well as c-Src kinase-dependent phosphorylation have been implicated in the loosening of cell-cell contacts, thereby modulating vascular permeability. Here we demonstrate that BMP6 induces hyperpermeabilization of human endothelial cells by inducing internalization and c-Src- dependent phosphorylation of VE-cadherin. Furthermore, we show BMP-dependent physical interaction of VE-cadherin with the BMP receptor ALK2 (BMPRI) and BMPRII, resulting in stabilization of the BMP receptor complex and, thereby, the support of BMP6-Smad signaling. Our results provide first insights into the molecular mechanism of BMP-induced vascular permeability, a hallmark of various vascular diseases, and provide the basis for further investigations of BMPs as regulators of vascular integrity, both under physiological and pathophysiological conditions.

ACVR1 ; ALK2 ; BMP ; BMPR2 ; Cadherin 5 ; Endothelial cells ; Permeability ; Src ; VE-cadherin

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

129 (1)

2016.

206-218

objavljeno

0021-9533

10.1242/jcs.179960

Povezanost rada

nije evidentirano

Poveznice
Indeksiranost