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Pregled bibliografske jedinice broj: 810303

Časopis

Autori: Šimić, Goran; Babić Leko, Mirjana; Wray, Selina; Harrington, Charles; Delalle, Ivana; Jovanov-Milošević, Nataša; Bažadona, Danira; Buée, Luc; de Silva, Rohan; Di Giovanni, Giuseppe; Wischik, Claude; Hof, Patrick R.
Naslov: Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
Izvornik: Biomolecules (2218-273X) 6 (2016), 1; 1-28
Vrsta rada: članak
Ključne riječi: Alzheimer’s disease; amyloid; neurofibrillary degeneration; microtubules; neuropathology; phosphorylation; protein aggregation; protein oligomerization; tauopathies; tau protein
Sažetak:
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases, including Alzheimer’s disease (AD). AD is characterized by the extraneuronal deposition of the amyloid beta protein in the form of plaques and the intraneuronal aggregation of the microtubule-associated protein tau in the form of filaments. Based on the biochemically diverse range of pathological tau proteins, a number of approaches have been proposed to develop new potential therapeutics. Here we discuss some of the most promising ones: inhibition of tau phosphorylation, proteolysis and aggregation, promotion of intra- and extracellular tau clearance, and stabilization of microtubules. We also emphasize the need to achieve a full understanding of the biological roles and post-translational modifications of normal tau, as well as the molecular events responsible for selective neuronal vulnerability to tau pathology and its propagation. It is concluded that answering key questions on the relationship between amyloid beta and tau pathology should lead to a better understanding of the nature of secondary tauopathies, especially AD, and open new therapeutic targets and strategies.
Projekt / tema: HRZZ IP-2014-09-9730, HRZZ-09/16, 108-1081870-1942
Izvorni jezik: ENG
Current Contents: NE
Citation Index: DA
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Tiskani medij: da
URL Internet adrese: http://www.mdpi.com/2218-273X/6/1/6
Broj citata:
Altmetric:
DOI: 10.3390/biom6010006
Google Scholar: Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
Upisao u CROSBI: Goran Šimić (gsimic@hiim.hr), 19. Tra. 2016. u 08:38 sati



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