engleski

Molecular diversity of HIV- in Croatia

HIVG1 comprises four distinct lineages or groups: major (M), outlier (O), nonGmajor, nonGoutlier (N) and P that originated via independent crossGspecies transmission events. Group M represents the pandemic form of HIVG1 and is classified into 9 subtypes with numerous circulating recombinant forms (CRF). Molecular diversity of HIVG1 in Croatia has been analyzed in 120 newlyGdiagnosed patients entering clinical care at the Reference center for HIV/AIDS in the period 2006G2008. Subtype B was detected in 106/120 (88%) patients whereas nonGB subtypes included subtype A (n = 6, 5%), subtype C (n = 4, 3.3%), CRF02_AG (n = 2 patients, 1.7%), CRF01_AE (n = 1, 0.8%), and subtype D (n = 1, 0.8%). The majority of patients infected with subtype B were males (n=103, 97.2%), mainly men who have sex with men (MSM, n=78, 75.6%) whereas 10/14 patients with nonGB subtypes were heterosexual. More recent studies on patients entering clinical care during 2013 also showed the predominance of subtype B (25 of 30 patients), mainly in MSM. In conclusion, the majority of HIVG1 infections in Croatia correspond to subtype B but nonGB subtypes continue to be introduced, mainly via heterosexual transmission.

HIV

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