engleski

RENAL ALLOGRAFT FUNCTION AND INCIDENCE OF REJECTION EPISODES DURING THE EARLY POSTTRANSPLANT PERIOD

Purpose: To determine the influence of acute allograft injury with kidney transplantation on the incidence of rejection episodes within the first three months, and on one year patient and graft survival at our center. Materials and methods: We reviewed cadaver kidney transplants carried out consecutively at our center from 2007 until 2012. Four recipients were excluded from the study due to early allograft loss caused by surgical complications and one case due to primary non-function of unclear reason. Acute allograft injury was registered in case of poor graft function in the first week after transplantation. Results: Among 85 transplant recipients, acute allograft injury occured in 60 (70.6%) recipients with transplantation and almost half of them (45.0%) required dialysis. Within the first three months, 9 (10.6%) patients were treated due to allograft rejection episodes (in five cases biopsy-proven). In recipients with acute allograft injury, the incidence of rejection episodes within the first three months was 11.7% vs 8% in patients with immediate recovery of graft function (p=0.981). At one year, the incidence of patients with good graft function (eGFR ≥60 ml/min/1.73m2) was higher in the patient group with immediate recovery of graft function (p=0.038), but there was no difference in one year patient and graft survival. Conclusions: Acute allograft injury with transplantation did not influence one year patient and graft survival, but it was related to a significantly impaired graft function at one year and a trend towards a higher incidence of acute rejection episodes.

kidney transplantation; acute allograft injury; early rejection; survival

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