Reduced evoked motor and sensory potential amplitudes in obstructive sleep apnoea patients. (CROSBI ID 227664)
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Mihalj, Mario ; Lušić, Linda ; Đogaš, Zoran
engleski
Reduced evoked motor and sensory potential amplitudes in obstructive sleep apnoea patients.
It is unknown to what extent chronic intermittent hypoxaemia in obstructive sleep apnoea causes damage to the motor and sensory peripheral nerves. It was hypothesized that patients with obstructive sleep apnoea would have bilaterally significantly impaired amplitudes of both motor and sensory peripheral nerve-evoked potentials of both lower and upper limbs. An observational study was conducted on 43 patients with obstructive sleep apnoea confirmed by the whole-night polysomnography, and 40 controls to assess the relationship between obstructive sleep apnoea and peripheral neuropathy. All obstructive sleep apnoea subjects underwent standardized electroneurographic testing, with full assessment of amplitudes of evoked compound muscle action potentials, sensory neural action potentials, motor and sensory nerve conduction velocities, and distal motor and sensory latencies of the median, ulnar, peroneal and sural nerves, bilaterally. All nerve measurements were compared with reference values, as well as between the untreated patients with obstructive sleep apnoea and control subjects. Averaged compound muscle action potential and sensory nerve action potential amplitudes were significantly reduced in the nerves of both upper and lower limbs in patients with obstructive sleep apnoea compared with controls (P < 0.001). These results confirmed that patients with obstructive sleep apnoea had significantly lower amplitudes of evoked action potentials of both motor and sensory peripheral nerves. Clinical/subclinical axonal damage exists in patients with obstructive sleep apnoea to a greater extent than previously thought.
axonal sensorimotor polyneuropathy ; compound motor action potentials ; intermittent hypoxia ; sensory nerve action potentials ; sleep apnoea
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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