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Adiponectin and glucagon-like peptide 1 in C-peptide negative type 1 diabetic patients with retinopathy: a cross-sectional study

The aim of the study was to investigate the association between adiponectin (ADPN) and glucagon-like peptide 1 (GLP-1) with diabetic retinopathy (DR) and correlation of ADPN with GLP- 1 in C-peptide negative type 1 diabetic mellitus (T1DM) patients. ADPN and GLP-1 concentrations were measured by ELISA in a cross-sectional study that included 76 patients, age 45 (19-65) and disease duration 22 (1-47) years. The severity of DR was evaluated according to the EURODIAB classification. Data were statistically analyzed by SPSS with a significance level P<0.05. Patients with proliferative DR had higher ADPN (24.4±6.8 μg/mL) in comparison to nonproliferative DR patients (16.8±7.2 μg/mL) and without DR (12.3±4.7 μg/mL) adjusted for age, disease duration and renal function (P for trend 0.035). Binary logistic regression showed that ADPN remained independently associated with DR prevalence (OR 1.129, 95%CI 1.001-1.273). GLP-1 was not associated with DR or ADPN. ADPN correlated with the severity of DR in T1DM patients, whereas such relationship was not observed for GLP-1.

diabetic retinopathy; adiponectin; glucagon-like peptide 1; C-peptide negative; type 1 diabetes mellitus

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