Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes (CROSBI ID 227947)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lin, Yen Ting ; Frömberg, Daniela ; Huang, Wenwen ; Delivani, Petrina ; Chacón, Mariola ; Tolić, Iva M. ; Jülicher, Frank ; Zaburdaev, Vasily
engleski
Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes
During recombination, the DNA of parents exchange their genetic information to give rise to a genetically unique offspring. For recombination to occur, homologous chromosomes need to find each other and align with high precision. Fission yeast solves this problem by folding chromosomes in loops and pulling them through the viscous nucleoplasm. We propose a theory of pulled polymer loops to quantify the effect of drag forces on the alignment of chromosomes. We introduce an external force field to the concept of a Brownian bridge and thus solve for the statistics of loop configurations in space.
DNA recombination ; chromosome folding
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Podaci o izdanju
115
2015.
208102-1-208102-5
objavljeno
0031-9007
10.1103/PhysRevLett.115.208102