Glycosylation Profile of IgG in Moderate Kidney Dysfunction (CROSBI ID 228580)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Barrios, Clara ; Zierer, Jonas ; Gudelj, Ivan ; Štambuk, Jerko ; Ugrina, Ivo ; Rodríguez, Eva ; Soler, María José ; Pavić, Tamara ; Šimurina, Mirna ; Keser, Toma ; Pučić-Baković, Maja ; Mangino, Massimo ; Pascual, Julio ; Spector, Tim D. ; Lauc, Gordan ; Menni, Cristina
engleski
Glycosylation Profile of IgG in Moderate Kidney Dysfunction
Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5×10(-4)) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.
clinical nephrology ; glycation ; renal function decline
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Podaci o izdanju
27 (3)
2016.
933-941
objavljeno
1046-6673
10.1681/ASN.2015010109
Povezanost rada
Biologija, Temeljne medicinske znanosti, Farmacija