Organometallic ruthenium complexes with triphenylphosphane amino acid bioconjugates: Catalytic and biological properties (CROSBI ID 635869)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kokan, Zoran ; Brozovic, Anamaria ; Piantanida, Ivo ; Turel, Iztok ; Kirin, Srećko I.
engleski
Organometallic ruthenium complexes with triphenylphosphane amino acid bioconjugates: Catalytic and biological properties
Amino acid bioconjugates of triphenlyphosphanes are successfully used as monodentate ligands in rhodium catalyzed asymmetric hydrogenations. A major feature of those metal complexes is the formation of chiral secondary structure responsible for chiral induction in the catalytic cycle. Apart from their excellent catalytic properties, organometallic ruthenium complexes with nitrogen or phosphane ligands showed promising results in cytotoxicity studies. In addition, the catalytic activity of ruthenium complexes has recently been used as a new approach to anticancer drug design. Herein, we explore the synthesis and characterization of (p-cymene)ruthenium complexes 1 and 2, bearing phosphane ligands with chiral or non-chiral amino acid esters. The spacer between the phosphorus and the amino acid was varied in order to investigate hydrogen bonding propensity of the amino acid substituents. Catalytic and biological properties will be reported.
rhodium catalyzed asymmetric hydrogenations
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Podaci o prilogu
84-84.
2016.
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objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts
Podaci o skupu
4th Whole Action Meeting of the COST Action CM1105 and 3rd International Symposium on Functional Metal Complexes that Bind to Biomolecules
poster
28.04.2016-29.04.2016
Palma de Mallorca, Španjolska