engleski

OCCUPATIONAL AIRBORNE CONTACT DERMATITIS TO OMEPRAZOLE

Omeprazole is a proton pump inhibitor for the treatment of gastric acid-related disorders. It is administered orally. We present 52-years-old chemist who worked in a pharmaceutical company for 5 years and she was exposed to omeprazole during the manufacturing process. When working in the laboratory, she was wearing protective latex free gloves. Whenever they were manufacturing omeprazole she had eczema with scaling on the eyelids face and neck, later hands were also affected. When she was on sick leave or when she was on vacation she had completely regression of skin dermatitis. The patient was treated with topical corticosteroids, which resulted with temporally regression of skin symptoms. We preformed lymphocyte transformation test (LTT) which was negative. Patch test to baseline series was negative, but patch test to omeprazole (0.1% and 0.5% in saline solution) was positive at day 2 (+) and day 3 (++). Conclusions: Omeprazole constitute a high- sensitizing chemical. Although direct contact with the skin is not always present, distribution of dust containing omeprazole through the air and deposition on exposed areas may result in an airborne pattern of contact dermatitis. Our case confirms the risk of sensitization to omeprazole from occupational exposure.

Omeprasole; proton pump inhibitor; eczema

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