The role of insulin-like growth factor 2 and its receptors in human tumors (CROSBI ID 94674)
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Podaci o odgovornosti
Pavelić, Krešimir ; Buković, Damir ; Pavelić, Jasminka
engleski
The role of insulin-like growth factor 2 and its receptors in human tumors
Insulin-like growth factor 2 (IGF2) is important for normal development and growth of an organism. In humans it is encoded by 11p15.5 paternally expressed-imprinted gene. It binds at least two different types of receptors: IGF type 1 (IGF1R) and IGF1/mannose 6-phosphate receptors (IGF2R/M6P). Ligand binding to IGF1R provokes mitogenic and antiapoptotic effects. IGF2R/M6P has tumor suppressor function - it mediates IGF 2 degradation. When the IGF2 gene/protein is overexpressed, mostly as a consequence of loss of heterozygosity resulting in paternal allele duplication (LOH) or by loss of imprinting (LOI), it is involved in the development and progression of many tumors and overgrowth syndromes by autocrine or paracrine mechanisms.
IGF2; IGF1 and 2 receptor; tumor
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nije evidentirano
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nije evidentirano
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Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti