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Nerve response to electrical stimulation with repetitive subthreshold monophasic rectangular pulses – simulation study based on SENN nerve model

The study deals with nerve response to a long train of repetitive, rectangular monophasic pulses. The threshold current for repetitive stimuli was calculated and compared to the threshold current for single pulse excitation having the same phase duration, as well as to the rheobase current, for a wide range of phase durations and repetition frequencies. The study was carried out using the SENN (Spatially Extended Nonlinear Node) nerve model. The results indicate that nerve excitation by repetitive monophasic stimuli can be efficient even for subthreshold high-frequency pulses. This result is potentially interesting for both medical application protocols and human exposure studies.

subthreshold high frequency stimulation; repetitive monophasic pulses; SENN simulation; nerve equivalent time constant

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